Objetivo Vertebrate development is orchestrated by the coordinated deployment of multiple and diverse programs of cell commitment and differentiation. One of the fundamental questions in this process is how a discrete number of transcriptional programs and extracellular cues combine to produce the enormous cellular complexity that characterizes vertebrate organisms. This research aims at uncovering the general principles of how cellular diversity is created in the sensory nervous system.We aim to determine: 1/ the transcriptional programs directing the commitment and differentiation of different types of sensory neurons and 2/ how, when and where different types of sensory neurons are committed by genetic tracing. The proposed research takes advantage of multidisciplinary approaches including model systems and methods such as rapid screening of gene function in the chick, a boundary cap neural stem cell culture system, and advanced mouse genetics for revealing gene function and for lineage tracing. Ámbito científico natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesgeneticsmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineneurology Palabras clave Cell Type Specification Neural Crest Sensory System Stem Cells Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Convocatoria de propuestas FP6-2005-MOBILITY-5 Consulte otros proyectos de esta convocatoria Régimen de financiación EIF - Marie Curie actions-Intra-European Fellowships Coordinador KAROLINSKA INSTITUTET Aportación de la UE Sin datos Dirección Nobels väg 5 STOCKHOLM Suecia Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos
