Objectif It is generally assumed that the brain generates behavior through the electrical activity of neurons. Information coding relies on coordinated activity of neuronal assemblies. This cooperative activity of central neurons is embodied in the oscillations and synchronization of neuronal activity among different frequencies bands. The mechanisms allowing the emergence of neuronal oscillations are variable and include fast synaptic transmission and electrical coupling between interneurons or principal cells but their speific role in each frequency domain remains to be elucidated. The implication of inerneuronal gap junctions in hippocampal gamma oscillations has been demonstrated using mice lacking the neuronal connexin gene Cx36. However, the study of the implication of electrical synapses in theta oscillations and ripples (ultrafast oscillations) has led to controversial results, and suggests that other coupled networks expressing other connexins might be involved. This project (outgoing phase) aims at testing the impact of different ellectrically coupled networks (interneurons and pyramidal cells) in hippocampal network activity and hippocampus-dependent learning. For this purpose, hippocampal rhythms will be compared in Cx36 (expressed in interneurons) knocked-out mice, and Cx36 and Cx45 (expressed in pyramidal cells) double KO mice. This will be done using large-scale recordings of unit activity and local-field potential recordings in animals chronically implanted with 16-site silicon probes, during spontaneous episodes of slow-wave and rapid eye movement sleep, wheel running and alternation task. During this post-doctoral training, I will learn large-scale recordings and analysis of neuronal population activity in the hippocampus in behaving animals. The return phase will be dedicated to the application of these techniques in basal ganglia structures, where neuronal oscillations are a crucial pathophysiological issue, notably in Parkinson's disease. Champ scientifique medical and health sciencesbasic medicineneurologyparkinsonnatural scienceschemical sciencesinorganic chemistrymetalloids Mots‑clés Neurobiology Neurophysiology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) PEOPLE-2007-4-1.IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Appel à propositions FP7-PEOPLE-2007-4-1-IOF Voir d’autres projets de cet appel Régime de financement MC-IOF - International Outgoing Fellowships (IOF) Coordinateur INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Contribution de l’UE € 230 963,71 Adresse RUE DE TOLBIAC 101 75654 Paris France Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Laurent Venance (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
