Descrizione del progetto Virtual Physiological Human Mostra l’obiettivo del progetto Nascondi l’obiettivo del progetto Many drugs fail to reach the market because of side effects on the heart. The principal objective of this proposal is to create an advanced computational technology for in silico assessment of the efficacy and safety of specific drugs [ICT-2007.5.3(c) (3)], i.e. an open environment comprising validated computational models, tools and numerical methods that will enable simulations of drug actions on the electrophysiology of the human heart. Such simulations will involve modelling of drug interactions at the molecular and cellular level, will extend current technology to enable prediction of the effects of those interactions on the dynamics of the whole heart, and will lead to an understanding of how genetic factors can be used to assess patient-specific risk profiles. This requires a multi-level systems approach, based on multi-scale, multi-physics methods, including computations on adaptive spatial grids and multi-grid time integration. Computations on realistic models at appropriate spatial and temporal scales are currently not feasible, so we will investigate new algorithms and their implementation on high-performance platforms, including a new generation of petaflop computers, to achieve faster than real-time simulation. These tools form part of the infrastructure required to simulate the physiology of major organ systems, thereby contributing to the goal of creating the Virtual Physiological Human (VPH) [ICT-2007.5.3]. The balanced team in this project, including founders of the Human Physiome Project, has decades of experience in the experimental study and modelling of the electrophysiology and mechanics of the heart, while pharmaceutical industry partners bring deep understanding of the mechanisms of drug actions. The results will demonstrate the value of the VPH initiative to fundamental scientific understanding of the heart, with major economic and clinical impacts through accelerated drug development, approvaland use. Campo scientifico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesbasic medicinephysiologynatural sciencescomputer and information sciencescomputational sciencemultiphysicsnatural sciencesmathematicsapplied mathematicsnumerical analysis Programma(i) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Argomento(i) ICT-2007.5.3 - Virtual physiological human Invito a presentare proposte FP7-ICT-2007-2 Vedi altri progetti per questo bando Meccanismo di finanziamento CP - Collaborative project (generic) Coordinatore THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Contributo UE € 2 121 143,00 Indirizzo WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Regno Unito Mostra sulla mappa Regione South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Stephen Conway (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto NOVARTIS PHARMA AG Svizzera Contributo UE € 0,00 Indirizzo LICHTSTRASSE 35 4056 Basel Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Antoine Soubret (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato F. HOFFMANN-LA ROCHE AG Svizzera Contributo UE € 0,00 Indirizzo GRENZACHERSTRASSE 124 4070 Basel Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Liudmila Polonchuk (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITAT POLITECNICA DE VALENCIA Spagna Contributo UE € 517 211,00 Indirizzo CAMINO DE VERA SN EDIFICIO 3A 46022 Valencia Mostra sulla mappa Regione Este Comunitat Valenciana Valencia/València Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo José Antonio Pérez García (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato AUREUS PHARMA SA Francia Contributo UE € 765 000,00 Indirizzo QUAI DE JEMMAPES 174 75010 PARIS 10 Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Laurence RIOT-LAMOTTE (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato SZEGEDI TUDOMANYEGYETEM Ungheria Contributo UE € 69 500,00 Indirizzo DUGONICS TER 13 6720 Szeged Mostra sulla mappa Regione Alföld és Észak Dél-Alföld Csongrád Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo István Baczkó (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato CENTRO DI RICERCA, SVILUPPO E STUDI SUPERIORI IN SARDEGNA SOCIETÀ A RESPONSABILITÀ LIMITATA Italia Contributo UE € 327 600,00 Indirizzo LOCALITA PISCINA MANNA EDIFICIO 1 09050 Pula Cagliari Mostra sulla mappa Tipo di attività Research Organisations Contatto amministrativo Alessandro Milletti (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FUJITSU LABORATORIES OF EUROPE LIMITED Regno Unito Contributo UE € 299 546,00 Indirizzo HAYES PARK CENTRAL, HAYES END ROAD UB4 8FE HAYES Mostra sulla mappa Regione London Outer London — West and North West Harrow and Hillingdon Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Ryoko Attwell (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. Regno Unito Contributo UE € 0,00 Indirizzo Great West Road 980 TW89GS Brentford Mostra sulla mappa Regione London Outer London — West and North West Hounslow and Richmond upon Thames Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Nick McMahon (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
