Objective
Cancer is often characterized as a disease of signal transduction pathways, since it is frequently associated with inappropriate activation of such pathways. Indeed, new therapeutic approaches in cancer therapy, such as Herceptin, frequently target signaling pathway components to revert their pathophysiological aberrations. Most oncogenic pathways have been highly conserved throughout evolution with Drosophila representing a particularly powerful genetic model for the analysis of such signaling cascades. These cancer pathways include Wnt, Notch, Hippo and JAK/STAT pathways. The analysis of signaling pathways in Drosophila is facilitated by the availability of a broad range of genetic tools, a completely sequenced genome and the availability of genome-wide collections of RNAi reagents. Within this project, we will establish high-throughput cell-based assays for regulators of the major developmental oncogenic signaling pathways. Cell-based assays for signaling pathways will be screened using genome-wide RNAi and small molecule compound libraries to identify new components, regulators and targets. Suppressor/enhancer screens in cultured cells will be used to identify small molecular compounds that interfere with the activity of specific signaling pathways and in vivo models of signaling pathways will be established to test the activity of drugs using developmental and tumorogenic phenotypes. By integrating and standardizing data from most important cancer relevant signaling pathways and combining them with powerful bioinformatics tools, we expect to get highly validated information on possible drug targets and lead substances. The collaborative project integrates recent technological advances, such as genome-wide RNAi libraries for cell-based and in vivo assay models that were developed by the participants, as well as computational approaches and databases to integrate and disseminate the information obtained during the project.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences computer and information sciences databases
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2007-A
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69120 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.