Objective
This project aims to advance our fundamental molecular understanding of metal homeostasis in plants, enabling the rational design of bio-fortification and phytoremediation technologies. Nutritional zinc deficiency affects more than a third of the World’s population. Also, large areas of soils in industrialized nations are contaminated with high levels of chemically similar harmful metals such as lead and cadmium. Since plants are a major route for the entry of both essential and toxic non-essential trace elements into the food chain, a comprehensive molecular understanding of metal homeostasis networks governing trace element accumulation in plants is highly desirable. Following from recent progress in the field, the proposed project will tackle three selected central aspects of plant zinc homeostasis. The role of low-molecular weight chelators in subcellular partitioning of zinc will be addressed through biochemical analysis of Arabidopsis thaliana ZIF1, a vacuolar membrane protein required for zinc tolerance, through combined reverse genetics, biochemistry and recently developed sub-cellular fractionation techniques. A forward genetic screen will identify genes within regulatory pathways governing zinc homeostasis, based on unique tools and technical expertise previously generated by the applicant. Finally, molecular regulatory links within the metal homeostasis network will be revealed by combining genetic resources uniquely available in the host lab and from the applicant, and subjecting them to genome-wide transcript profiling. This research will not only advance metal homeostasis, but also our general understanding of regulation and signalling in plants. By integrating unique tools, resources and knowledge between the applicant, his laboratory of origin in Australia and the European host lab, tight collaborative links will be established, thus accelerating scientific progress and fostering continued scientific exchange between Europe and Australia.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- engineering and technology environmental biotechnology bioremediation phytoremediation
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-2-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
44801 Bochum
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.