Objetivo This project aims to advance our fundamental molecular understanding of metal homeostasis in plants, enabling the rational design of bio-fortification and phytoremediation technologies. Nutritional zinc deficiency affects more than a third of the World’s population. Also, large areas of soils in industrialized nations are contaminated with high levels of chemically similar harmful metals such as lead and cadmium. Since plants are a major route for the entry of both essential and toxic non-essential trace elements into the food chain, a comprehensive molecular understanding of metal homeostasis networks governing trace element accumulation in plants is highly desirable. Following from recent progress in the field, the proposed project will tackle three selected central aspects of plant zinc homeostasis. The role of low-molecular weight chelators in subcellular partitioning of zinc will be addressed through biochemical analysis of Arabidopsis thaliana ZIF1, a vacuolar membrane protein required for zinc tolerance, through combined reverse genetics, biochemistry and recently developed sub-cellular fractionation techniques. A forward genetic screen will identify genes within regulatory pathways governing zinc homeostasis, based on unique tools and technical expertise previously generated by the applicant. Finally, molecular regulatory links within the metal homeostasis network will be revealed by combining genetic resources uniquely available in the host lab and from the applicant, and subjecting them to genome-wide transcript profiling. This research will not only advance metal homeostasis, but also our general understanding of regulation and signalling in plants. By integrating unique tools, resources and knowledge between the applicant, his laboratory of origin in Australia and the European host lab, tight collaborative links will be established, thus accelerating scientific progress and fostering continued scientific exchange between Europe and Australia. Ámbito científico natural sciencesbiological sciencesgeneticsengineering and technologyenvironmental biotechnologybioremediationphytoremediationnatural scienceschemical sciencesinorganic chemistrytransition metalsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinephysiologyhomeostasis Palabras clave Cell biology Functional biology Molecular biology Plant genetics Plant nutrition Plant physiology Soil remediation Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) PEOPLE-2007-4-2.IIF - Marie Curie Action: "International Incoming Fellowships" Convocatoria de propuestas FP7-PEOPLE-2007-4-2-IIF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IIF - International Incoming Fellowships (IIF) Coordinador RUHR-UNIVERSITAET BOCHUM Aportación de la UE € 169 250,31 Dirección UNIVERSITAETSSTRASSE 150 44801 Bochum Alemania Ver en el mapa Región Nordrhein-Westfalen Arnsberg Bochum, Kreisfreie Stadt Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Angelika Ernst (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG La participación finalizó Alemania Aportación de la UE Sin datos Dirección SEMINARSTRASSE 2 69117 Heidelberg Ver en el mapa Región Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Ute Krämer (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
