Objective
The scientific goal of this project is to use magnetoencephalography (MEG) and intracerebral electroencephalography (iEEG) to gain a better understanding of subcortical and abnormal cortical oscillatory dynamics. The first specific aim of this project is to apply the most sophisticated techniques currently available to resolve the activity of deep brain structures, such as the amygdala, hippocampus, brainstem, and cerebellum, using noninvasive MEG recordings. Time-frequency analysis may be better suited to the nature of the signals produced by these structures than traditional event-related averages. Therefore, advanced spatial filtering techniques will be combined with time-frequency analysis to produce five-dimensional space-time-frequency maps of brain activity. A realistic head model will be used in the construction of the spatial filters, enhancing the spatial resolution of deeper sources. The results will be validated and augmented with iEEG recordings from intractable epilepsy patients who receive clinically indicated depth electrode implants in these areas. Additionally, time-frequency analysis will be applied to EEG-based auditory brainstem response (ABR) recordings to investigate its utility compared to the thousands-of-trials average currently in clinical practice. The second specific aim is to examine the abnormal spontaneous oscillatory activity associated with tinnitus. Recent studies suggest that the phantom perception of many tinnitus patients arise from abnormal synchronization of auditory cortex. However, to date, most efforts in EEG/MEG source localization have concentrated on the localization of high-amplitude transient epileptic spikes or stimulus-evoked experimental designs. These methods require further technical development to allow the analysis of spontaneous changes in oscillatory activity. I propose to use adaptive spatial filtering techniques combined with time-frequency analysis to accomplish this aim.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine neurology epilepsy
- medical and health sciences clinical medicine otorhinolaryngology
- medical and health sciences medical biotechnology implants
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-2-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75654 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.