Objective
The discovery of cisplatin, cis-diamminedichloroplatinum(II), as an anticancer drug is a landmark of modern inorganic medicinal chemistry. Platinum drugs are the best-selling antitumor drugs in the world and they are effective in treating a variety of cancers. During the last decade, the search for new anticancer compounds has been widened to other transition metals. Ruthenium complexes in particular have shown considerable promise because of their rich synthetic chemistry, the range of oxidation states, the common octahedral geometry, and finally also because of their rich photochemistry. The fundamental goal of this project is to investigate the possibility of developing new types of hybrid ruthenium-based chemotherapeutic drugs that can be activated by irradiation with low-energy light. When irradiated these molecules form reactive aqua species and, at the same time, release biologically active ligands. The ligands can interfere with the cell cycle at a number of targets, while the metal-containing aqua species inhibit mitosis by binding to DNA. The proposed approach can lead to development of milder, more specific, and tunable drugs which can decrease the negative side-effects of chemotherapy. Inorganic and organic synthetic methodologies, advanced spectroscopic and analytical techniques will be used together with biochemical and medical methods to pursue the objectives of the project. The multi- and interdisciplinary nature of the research will prompt the applicant to acquire practical and theoretical skills on chemical biology and medical chemistry, to improve his independent thinking and leadership qualities, enhancing his scientific competencies and helping the applicant to attain an independent position.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences physical chemistry photochemistry
- natural sciences mathematics pure mathematics geometry
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CV4 8UW COVENTRY
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.