Objective Amine and peptide levels have been measured in brain samples form Parkinson's Disease (PD) patients as well as from controls both with and without Lewy bodies.Amine measurements showed that dopamine was reduced more in putamen than in caudate nucleus and that ventral subregions showed less alteration than dorsal subregions in PD. However, no differences were found between control samples with or without Lewy bodies.Peptide measurements showed parallel changes in striatal regions of PD samples and those controls with Lewy bodies. These alterations are neither secondary to dopamine nigrostriatal pathway degeneration nor antiparkinsonian therapy.Since the use of peptides as coadjuvants in PD therapy has been suggested, peptide receptors have also been studied. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesbasic medicineneurologyparkinsonnatural scienceschemical sciencesorganic chemistryamines Programme(s) FP1-STIMULATION 1C - Plan (EEC) to stimulate European scientific and technical cooperation and interchange, 1985-1988 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS EU contribution No data Address Calle Serrano 117 MADRID Spain See on map Links Website Opens in new window Total cost No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all Institute of Psychiatry United Kingdom EU contribution No data Address De Crespigny Park SE5 8AF London See on map Total cost No data
