Obiettivo "The dynamic nature of the brain operates at disparate time scales ranging from milliseconds to months. How do single neurons change over such long time scales? This question remains stubborn to answer in the field of brain plasticity mainly because of limited tools to study the physiology of single neurons over time in the complex environment of the brain. The research aim of this proposal is to reveal the physiological changes of single neurons in the mammalian brain over disparate time scales using time-lapse optical imaging. Specifically, we aim to establish a new team that will develop genetic and optical tools to probe the physiological activity of single neurons, in vivo. As a model system, we will study a unique neuronal population in the mammalian brain; the adult-born local neurons in the olfactory bulb. These neurons have tremendous potential to reveal how neurons develop and maintain in the intact brain because they are accessible both genetically and optically. By following the behavior of adult-born neurons in vivo we will discover how neurons mature and maintain over days and weeks. If our objectives will be met, this study has the potential to significantly ""raise the bar"" on how neuronal plasticity is studied and reveal some basic secrets of the ever changing mammalian brain." Campo scientifico natural sciencesbiological sciencesneurobiologynatural sciencesbiological scienceszoologymammalogyengineering and technologymedical engineeringdiagnostic imaging Parole chiave Plasticity olfaction Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-SG-LS4 - ERC Starting Grant - Physiology, Pathophysiology and Endocrinology Invito a presentare proposte ERC-2007-StG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-SG - ERC Starting Grant Istituzione ospitante THE HEBREW UNIVERSITY OF JERUSALEM Contributo UE € 1 750 000,00 Indirizzo EDMOND J SAFRA CAMPUS GIVAT RAM 91904 Jerusalem Israele Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Irit Harat (Ms.) Ricercatore principale Adi Mizrahi (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto THE HEBREW UNIVERSITY OF JERUSALEM Israele Contributo UE € 1 750 000,00 Indirizzo EDMOND J SAFRA CAMPUS GIVAT RAM 91904 Jerusalem Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Irit Harat (Ms.) Ricercatore principale Adi Mizrahi (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato