Objective
Understanding the structure and function of endomembrane compartments is central to a mechanistic understanding of eukaryotic cell behavior. Multi-cellular organisms show an increased complexity and specialization in their endomembrane trafficking pathways. Higher plants have independently developed multi-cellularity and show a differently structured, but highly complex endomembrane system that regulates numerous, fundamental processes, such as cell wall composition, plant nutrition or immune responses. However, the specificities of plant endomembrane trafficking are only insufficiently addressed by homology-based approaches, which are inherently biased and limited to modules and pathways that are conserved between animals/yeast and plants. I propose to address this by undertaking forward genetic approaches for regulators of endocytic trafficking in Arabidopis with newly developed tools. In addition, I will establish the root endodermis as a model to address the mechanism of epithelial polarity establishment in plants. Epithelia are a fundamental feature of multi-cellular organisms and have independently evolved in plants and animals. The root endodermis is a tissue of central importance for plant nutrition. It is accessible to analysis and displays all the defining features of an epithelium. Studying the endodermis will allow me to investigate how independent or conserved the mechanisms of epithelial polarity are. Apart from the immediate interest for a number of plant developmental and adaptive responses, I contend that both parts of my proposal are also of general, fundamental interest. Current comparisons between yeast and animals do not give us any reliable and coherent idea about what is truly fundamental or derived in eukaryotic membrane organization. Unbiased research on plant membrane trafficking will provide insight into an additional, divergent type of eukaryotic cell and allow a better appreciation of the evolution of eukaryotic membrane organization.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine physiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2007-StG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
1015 LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.