Objective
GENTRECAD builds on PROCARDIS, a large European integrated project designed to identify susceptibility genes for coronary artery disease (CAD). CAD has a complex multifactorial aetiology including a substantial heritable component. The current challenge addressed by GENTRECAD is to identify and characterise the genes and gene variants that are functionally implicated, as a basis for designing new targeted treatments and diagnostics. Inflammation plays a key role in the development of CAD. GENTRECAD will take a systematic approach to the in vivo identification and characterization of genomic regulatory regions and active binding sites of selected transcription factors that are expressed and control gene expression in inflammatory macrophages and aims at revealing common genetic variation that affects these processes. Expected deliverables include a limited number of key regulatory pathways in macrophages that are implicated in CAD. Secondly, novel bioinformatics tools will be provided for in silico prediction of regulatory elements and pathways. Results from GENTRECAD will be relevant to other common disabling multifactorial inflammatory diseases as well. Through GENTRECAD, the applicant will be trained in state-of-the-art methodologies in genomics, proteomics, applied bioinformatics and clinical genetics. The multidisciplinary nature of the project will develop her collaborative skills, promote in dependence and increase competitiveness.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences basic medicine medical genetics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.