Objective
A fundamental question facing physical chemistry and biology is to determine the basic mechanisms by which biological molecules react and change structure. Ultrafast two dimensional infrared (2D-IR) spectroscopy has emerged as an exciting new tool for probing the structure and dynamics of bio-systems. This proposal is the first concerted application of transient 2D-IR spectroscopy to answer pressing questions relating to reactions of biological systems. The unique combination of ultrafast time resolution and structural insight makes 2D-IR the perfect platform to observe real-time structure changes during reactions. We will exploit this ability by developing SPRITES – Structure changes in Protein Reactions via Infrared Time Evolution Spectroscopy. We will trigger reactions in peptide and enzyme systems and use 2D-IR as a time-delayed probe of molecular structure to follow them in unprecedented real-time detail. This ambitious project will be split into three stages for reasons of risk management: In stage one, simple photochemical reactions of model compounds of the hydrogenase enzyme active site will be initiated and the structural evolution of the reactants followed using 2D-IR. In stage two, the novel pH-jump SPRITES technique will be developed to study peptide folding reactions. These experiments will lead to a “molecular movie” of a folding peptide in a natural environment, representing a unique scientific development. The final stage of the project will use pH-jump SPRITES to initiate and observe the reaction of a complete hydrogenase enzyme. This ambitious final stage will yield unprecedented insight into the mechanisms of biological reactions. The purpose of the proposal is to assist the PI in consolidating the independence gained through the award of a prestigious EPSRC Fellowship. The proposal seeks funding to create a research team of two postdoctoral research associates and two PhD students. This team will be managed and directed by the PI.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences physical chemistry photochemistry
- humanities arts modern and contemporary art cinematography
- social sciences sociology governance crisis management
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences physical sciences optics spectroscopy
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2007-StG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
G1 1XQ Glasgow
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.