Objective
The prevalence of end stage renal disease (ESRD) continues to grow worldwide. Current treatment options for ESRD are peritoneal dialysis, haemodialysis, or renal transplantation, all of which have significant drawbacks both in terms of quality and quantity of life. In children and young adults, the most common cause of ESRD is vesicoureteric reflux (VUR), a condition where urine from the bladder re-enters the kidney. VUR creates an increased risk of urinary tract infection, predisposing to pyelonephritis, renal scarring, and in the most severe cases, ESRD. However, there is usually a time-window of several years from initial diagnosis of VUR to the development of ESRD, which presents an opportunity to design therapies aimed at preventing disease progression by repairing renal tissue before it becomes non functional. Recent advances in stem cell science and tissue engineering suggests that stem cell based therapies for reflux nephropathy could be feasible. The long-term aim is to explore the potential of resident kidney stem cells for renal replacement therapy in order to prevent susceptible children from developing ESRD. In this project, the potential of resident kidney stem cells will be tested by transplantation into mouse embryonic kidneys ex vivo. To devise a suitable scaffold to, a range of biocompatible polymeric substrates will be fabricated and tested for their ability to support nephrogenesis from disaggregated mouse kidney rudiments in vitro. Finally, we will develop a magnetic nanoparticle-based cell tracking technique that will enable the transplanted cells to be monitored in vivo using magnetic resonance imaging. Results generated by the project will establish if kidney stem cells have potential for future use in regenerative medicine. Should the results prove positive, further work will determine if the isolated kidney stem are capable of generating nephrons in animal models in vivo.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine urology
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine transplantation
- medical and health sciences clinical medicine nephrology renal dialysis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-2-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
L69 7ZX LIVERPOOL
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.