Objective
Metastatic breast, ovarian, gastric and esophageal cancer are currently incurable and therefore require new and innovative treatment approaches. The objective of this project is to construct oncolytic adenoviruses that code for trastuzumab (HerceptinR), a monoclonal antibody against tumor associated receptor Her2. Intravenous trastuzumab is already widely used for treatment of Her2+ breast cancer, and is being actively studied for other tumor types that frequently feature Her2 amplification, including ovarian, gastric and esophageal cancer. We hypothesize that expression of the antibody from a virus will result in production of high, sustained concentrations of functional trastuzumab in situ. In comparison to conventional intravenous delivery, this might results in enhanced anti-tumor activity but reduced systemic exposure and side-effects. Further, a single injection of the virus might result in prolonged production of trastuzumab which might be cost-effective as intravenous trastuzumab is expensive. The viruses will be targeted for effective delivery to tumor cells through viral capsid modifications, and oncolytic cell killing will proceed only in p16/Rb pathway mutant tumor cells. Trastuzumab production will be coupled to virus replication. Further, trastuzumab is secreted into the surrounding tumor tissue for an effective “bystander effect”, ie. killing of neighboring tumor cells. In summary, we hypothesize that this approach will result in tumor cell killing through viral oncolysis, the anti-tumor activity of trastuzumab, and the potential synergy between the approaches. Further, high local concentrations might result in anti-tumor efficacy superior to efficacy seen with intravenous trastuzumab. These developments might eventually result in increased treatment options for patients with currently incurable Her2+ cancers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology virology
- medical and health sciences clinical medicine oncology breast cancer
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2007-StG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
00014 HELSINGIN YLIOPISTO
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.