Dynamics and stability of covalent protein modifications

Projektinformationen

PROTMOD

ID Finanzhilfevereinbarung: 203475

Abgeschlossenes Projekt

Startdatum 1 September 2008

Enddatum 31 August 2014

Finanziert unter

• Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 1 239 400,00

EU-Beitrag € 1 239 400,00

Koordiniert durch

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France

Ziel

"One of the major goals of post-genomic biological research is to understand the molecular basis and physiological role of covalent protein modifications. Post-transcriptional modifications can regulate protein interactions and/or stability and thus trigger particular downstream responses. A major challenge is to understand how modifications of histone proteins are translated into changes in gene expression and chromatin structure and how they regulate genome function. However, the significance of studying protein modifications extends beyond the field of chromatin research, because changes in the modification pattern are likely to affect many -if not all- biological processes. This proposal is designed to study and functionally characterise modifications of histones. The goals of this proposal are: A) Determining the role of linker H1 modifications and variants in epigenetic regulation of gene expression. This will enable us to expand the ""histone"" code to the next higher level of chromatin organisation. B) To identify yet uncharacterised sites or new types of histone modifications. This will be the basis for determining the biological function of these modifications. Altogether this will lead us to decipher the role of covalent protein modifications in regulation of gene expression and how they are linked into biological networks . These projects will significantly expand the scope of my ongoing research and will only be possible with additional funding, which will allow me to establish cutting edge technology, additional in vivo model systems and new interdisciplinary collaborations."

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › biological sciences › genetics › genomes

Schlüsselbegriffe

• chromatin
• covalent protein modification
• histone
• methylation
• methylome

Programm/Programme

• FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• ERC-SG-LS2 - ERC Starting Grant - Genetics,Genomics,Bioinformatics and Systems Biology

Aufforderung zur Vorschlagseinreichung

ERC-2007-StG
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

ERC-SG - ERC Starting Grant

Gastgebende Einrichtung

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

Hauptforscher

Robert Schneider (Dr.)

Kontakt Verwaltung

Steve Brooks (Dr.)

• EU-Beitrag: € 905 902,00
• Adresse: Rue Laurent Fries 1 ; 67404 Illkirch Graffenstaden ; Frankreich
• Region: Grand Est › Alsace › Bas-Rhin
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten

Begünstigte (2)

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

Frankreich

Hauptforscher

Robert Schneider (Dr.)

Kontakt Verwaltung

Steve Brooks (Dr.)

• EU-Beitrag: € 905 902,00
• Adresse: Rue Laurent Fries 1 ; 67404 Illkirch Graffenstaden
• Region: Grand Est › Alsace › Bas-Rhin
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Beteiligung beendet

Deutschland

Kontakt Verwaltung

Martina Enderlein (Ms.)

• EU-Beitrag: € 333 498,00
• Adresse: HOFGARTENSTRASSE 8 ; 80539 Munchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten