Objetivo Biomimetic Organocatalysis – Development of Novel Synthetic Catalytic Methodology and Technology The objective of the proposed research is the design and development of unprecedented preassembled, modular, molecular factories. Inspiration comes from nature’s non-ribosomal peptide synthetases (NRPSs) and polyketide synthetases (PKSs). These large multifunctional enzymes possess catalytic modules with the capacity for recognition, activation and modification required for sequential biosynthesis of complex peptides and polyketides. Using nature as a role model we intend to design and prepare such catalyst “factories” synthetically and apply them in novel cascade reaction sequences. The single catalytic modules employed will be based on organocatalytic procedures, including enamine-, iminium-, as well as hydrogen bonding activation processes, but the potential scope is limitless. Organocatalysts have so far never been applied in a combined fashion utilizing their different activation mechanisms in multiple reaction cascades. Therefore, it is our intention to firstly demonstrate that such a production line approach is feasible and that these new catalyst systems can be applied in the synthesis of valuable enantiopure, biologically active, building blocks and natural products. Additionally, the extensive possibilities to vary organocatalyst modules in sequence will lead to science mimicking nature in its diversity. Ámbito científico natural scienceschemical sciencescatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Palabras clave Biomimetic Catalysis Organocatalysis Reaction development chemistry of biological systems Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-SG-PE4 - ERC Starting Grant - Physical and Analytical Chemical sciences Convocatoria de propuestas ERC-2007-StG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-SG - ERC Starting Grant Institución de acogida RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Aportación de la UE € 982 320,00 Dirección TEMPLERGRABEN 55 52062 Aachen Alemania Ver en el mapa Región Nordrhein-Westfalen Köln Städteregion Aachen Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Ernst Schmachtenberg (Prof.) Investigador principal Magnus Rueping (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Alemania Aportación de la UE € 982 320,00 Dirección TEMPLERGRABEN 55 52062 Aachen Ver en el mapa Región Nordrhein-Westfalen Köln Städteregion Aachen Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Ernst Schmachtenberg (Prof.) Investigador principal Magnus Rueping (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN La participación finalizó Alemania Aportación de la UE € 17 640,00 Dirección THEODOR W ADORNO PLATZ 1 60323 Frankfurt Am Main Ver en el mapa Región Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Christoph Denecke (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
