Obiettivo Biomimetic Organocatalysis – Development of Novel Synthetic Catalytic Methodology and Technology The objective of the proposed research is the design and development of unprecedented preassembled, modular, molecular factories. Inspiration comes from nature’s non-ribosomal peptide synthetases (NRPSs) and polyketide synthetases (PKSs). These large multifunctional enzymes possess catalytic modules with the capacity for recognition, activation and modification required for sequential biosynthesis of complex peptides and polyketides. Using nature as a role model we intend to design and prepare such catalyst “factories” synthetically and apply them in novel cascade reaction sequences. The single catalytic modules employed will be based on organocatalytic procedures, including enamine-, iminium-, as well as hydrogen bonding activation processes, but the potential scope is limitless. Organocatalysts have so far never been applied in a combined fashion utilizing their different activation mechanisms in multiple reaction cascades. Therefore, it is our intention to firstly demonstrate that such a production line approach is feasible and that these new catalyst systems can be applied in the synthesis of valuable enantiopure, biologically active, building blocks and natural products. Additionally, the extensive possibilities to vary organocatalyst modules in sequence will lead to science mimicking nature in its diversity. Campo scientifico natural scienceschemical sciencescatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Parole chiave Biomimetic Catalysis Organocatalysis Reaction development chemistry of biological systems Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-SG-PE4 - ERC Starting Grant - Physical and Analytical Chemical sciences Invito a presentare proposte ERC-2007-StG Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-SG - ERC Starting Grant Istituzione ospitante RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Contributo UE € 982 320,00 Indirizzo TEMPLERGRABEN 55 52062 Aachen Germania Mostra sulla mappa Regione Nordrhein-Westfalen Köln Städteregion Aachen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Ernst Schmachtenberg (Prof.) Ricercatore principale Magnus Rueping (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (2) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Germania Contributo UE € 982 320,00 Indirizzo TEMPLERGRABEN 55 52062 Aachen Mostra sulla mappa Regione Nordrhein-Westfalen Köln Städteregion Aachen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Ernst Schmachtenberg (Prof.) Ricercatore principale Magnus Rueping (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN Partecipazione conclusa Germania Contributo UE € 17 640,00 Indirizzo THEODOR W ADORNO PLATZ 1 60323 Frankfurt Am Main Mostra sulla mappa Regione Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Christoph Denecke (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
