Objetivo Neural circuits in the spinal cord, called central pattern generators (CPGs), can produce locomotor movements. The locomotor activity pattern is the result of the circuit design and the interplay between the firing properties of the CPG constituent neurons and their synaptic interactions. Spinal cord injury impairs the function of the locomotor circuitry and results in paralysis. An understanding of the molecular mechanisms of the assembly of the spinal locomotor circuitry, the function of its key excitatory components and the intrinsic plasticity in the healthy and injured spinal cord is a prerequisite for designing novel therapeutic methods to restore locomotor function after spinal cord lesion. The work-packages have been designed to elucidate the key molecular pathways responsible for the development and assembly of the spinal circuitry for locomotion. The intrinsic function and modulation the spinal circuitry will be examined in the healthy spinal cord by combining sophisticated molecular, anatomical, pharmacological and electrophysiological tools. The mechanisms of plasticity and reorganization of the circuitry will be examined in the injured spinal cord as will the mechanism to promote regeneration of the lesioned axons. This project will integrate knowledge on the development and normal spinal cord function together with biological interventions aiming at protecting and repairing the injured spinal cord. The gained understanding will offer molecular and cellular foundations that will be instrumental in developing strategies for restoring motor function following spinal cord injury. Ámbito científico natural sciencesbiological sciencesneurobiology Palabras clave Locomotor circuitry development extracellular matrix locomotor training modulation regeneration Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH-2007-2.2.1-5 - From basic spinal mechanisms to spinal cord disease and trauma Convocatoria de propuestas FP7-HEALTH-2007-A Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador KAROLINSKA INSTITUTET Aportación de la UE € 1 487 600,00 Dirección Nobels Vag 5 17177 Stockholm Suecia Ver en el mapa Región Östra Sverige Stockholm Stockholms län Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Therese Sjöblom (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Reino Unido Aportación de la UE € 338 400,00 Dirección TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Ver en el mapa Región East of England East Anglia Cambridgeshire CC Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Dawn Barker (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos University of Zurich Suiza Aportación de la UE € 682 200,00 Dirección RAMISTRASSE 71 8006 ZURICH Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Huub Van Hedel (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos DANDO WEISS & COLUCCI LIMITED Reino Unido Aportación de la UE € 149 000,00 Dirección LOWER BRISTOL ROAD MINERVA HOUSE BA2 9ER BATH Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Jeffrey Dando (Mr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos Novartis Forschungsstiftung Suiza Aportación de la UE € 340 800,00 Dirección Maulbeerstrasse 66 4058 BASEL Ver en el mapa Tipo de actividad Research Organisations Contacto administrativo Dorothy Searles (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos