Objective
Chemokines and their receptors (GPCRs –G-Protein Coupled Receptors) play important roles in biological processes such as embryonic development, inflammation, immunity and cancer. Therefore, a great amount of effort is directed to study their function and regulation. The SDF1 chemokine receptors, CXCR4 and CXCR7, are expressed by a wide range of human metastasis. They can also act as co-receptors for HIV-1 infection. Thus, these GPCRs have become important therapeutic targets. Tumour metastasis, as well as morphogenesis and wound healing involve the migration of cells as highly organized three-dimensional groups or as tissues. One such tissues is the zebrafish posterior lateral line primordium (pLLP), a group of about 100 cells that performs a stereotyped migration along the flanks of the embryo. As it migrates, the pLLP undergoes morphogenesis to generate seven to eight mechanosensory hair cell organs that it leaves in its wake. The pLLP migrates along a stripe of SDF1. CXCR4b is required at the leading edge while CXCR7 is expressed exclusively in the trailing cells which slow down and are deposited. Using the pLLP migration as a model system, I intend to study in vivo how the differential activation of two GPCRs responding to SDF1 can control different cell behaviours.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences developmental biology
- medical and health sciences clinical medicine oncology
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69117 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.