Objective
I propose to analyze how epithelial cell shape is controlled, using the Drosophila peripodial membrane as a model system. Drosophila third instar imaginal discs are a composed of two contiguous layers of cells of distinct morphology: a pseudostratified one, called the proper epithelium (PE), and a squamous epithelium, the peripodial membrane (PM). While the PE has been deeply studied, little is known about the PM. The peripodial membrane has the ability to change its shape in response to ecdysone; it is proposed that this change is responsible for the eversion of the disc during metamorphosis. I propose to study the control of cell shape in the PM by two perspectives. First, I will look for the factors involved in specifying and maintaining the shape of the PM cells. Second, I will examine the dynamic process of disc eversion, and analyse what shape changes the cells undergo, and what factors and cellular rearrangements are responsible for this fundamental morphological process. For this purpose I have developed a technique that allows me to watch dissected live discs, and to follow the eversion in vitro using confocal live imaging. Amongst other mechanisms, I am currently analysing the role of myosin II in this process as well as looking for new factors that may be involved.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
W1B 1AL LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.