Objective
The cerebral cortex is one of the most complex and important structures in our brain. In correlation with its elaborate functions, the neocortex comprises a huge diversity of neuronal types, each cortical neuron displaying specific patterns of differentiation and connectivity. During development, embryonic progenitors sequentially generate the diverse repertoire of neuronal subtypes that will form the cortex (from early-born Cajal-Retzius neurons to later-generated pyramidal neurons). The molecular mechanisms accounting for this striking capacity of cortical progenitors to generate all types of neurons are unknown. The aim of my project is to identify the mechanisms of cortical neurogenesis that further have crucial implications for our understanding of pathological brain development and for the rational design of replacement therapies of neurodegenerative diseases. In this matter, the host lab (Dr Pierre Vanderhaeghen lab) has developed a particularly adequate model. In this system, murine embryonic stem (ES) cells efficiently generate neurons that share all landmarks of genuine neurons of the cerebral cortex. Strikingly, developing neurons recapitulate the major milestones of in vivo development, including the sequential generation of distinct subtypes of neurons. In this unique model of temporal neurogenesis, I will test candidate genes such as the transcription factors FoxG1, Sp8 (both affecting mammalian brain development through unknown mechanisms), and Chinmo homologues zBTB20-24 (Chinmo affecting temporal neurogenesis in drosophila), using an inducible system of gene expression. By microarrays experiments I will determine the gene expression profiling of generated neurons. This will allow to look for gene signatures of cortical neurons generated from ES cells, and to identify other genes associated with cortical neurogenesis. Attractive candidates will be tested in vitro and then in vivo in the mouse for their physiological relevance.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1050 Bruxelles / Brussel
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.