Objetivo The knowledge on regulatory roles of epigenetic mechanisms (heritable changes in the genome function without a change in the DNA sequence) has grown very fast during the last decade since they can be the target for treating several pathologies related to cancer and neurodegeneration. In the base of these diseases have also been found deficiencies in DNA repair mechanisms. In this respect, two human syndromes (Xeroderma Pigmentosum and Cockayne’s Syndrome) affecting one of the major DNA repair systems in human cells called nucleotide excision repair, characterized by sensitivity to UV irradiation, become an interesting model to contribute to unravel the link between chromatin remodeling processes and DNA repair. Expected results on the possible influence of chromatin remodeling processes to the higher sensitivity to UV radiation of Cockayne’s Syndrome cells will lead to perform further investigations to understand how these mechanisms are involved in the development of cancer and/or neurodegeneration found in these patients. Since the proposed investigation require a multidisciplinary study (cytogenetics, molecular biology and immunocytochemestry), it will become of the utmost importance not only for the research activity planned to carry out at the Laboratory of Prof. Palitti, since this line of research fits very well with the purposes already established by the Network of Excellence (NoE – Epigenetic Network created by several laboratories from Europe) supported by the FP6 program from the European Community; but also for having the possibility to incorporate new methodologies and strategies to continue with the study of possible links between epigenetic and DNA repair in our laboratory in Uruguay with the aim to initiate studies on epigenetic therapy mainly applied to facilitate chemotherapy treatment of cancer diseases. Ámbito científico natural sciencesbiological sciencesgeneticsepigenetics Palabras clave Molecular genetics UV-C apoptosis chromatin remodelling Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) PEOPLE-2007-4-2.IIF - Marie Curie Action: "International Incoming Fellowships" Convocatoria de propuestas FP7-PEOPLE-2007-4-2-IIF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IIF - International Incoming Fellowships (IIF) Coordinador UNIVERSITA DEGLI STUDI DELLA TUSCIA Aportación de la UE € 233 872,25 Dirección VIA S MARIA IN GRADI 4 01100 Viterbo Italia Ver en el mapa Región Centro (IT) Lazio Viterbo Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Daniela Cicalini (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
