Objective
Biogenic monoamines are relevant to influential psychological diseases and brain plasicity. Knowledge obtained so far is however not enough for both of scientific and medical purposes. One obstacle against proceeding is the difficulty to find novel genes in genetically-inaccessible system like human brain. Another problem is the complexity of brain making it difficult to link cellular phenomena to behavior, which is necessary to understand brain. To solve these problems, a genetically-accessible model organism C. elegans was introduced. With only 302 neurons, nervous system of C. elegans still has many properties common to the higher animal’s brain, including usage of monoamines and their roles in neural plasticity. Studies so far in C. elegans have provided much information by using mutants, exogenous amine application and neuron ablation. However, these methods have not considered dynamic property of aminergic system. Here, the applicant uses the genetically-encoded light-gated cation channel channelrhodopsin-2 (ChR2). Because the body of C. elegans is transparent, by expressing and light-activating ChR2 specifically in aminergic neurons, one can examine the amine effectss on behavior with precise time resolution. The automated behavior quantification system makes it possible to identify any subtle behavioral changes caused by aminergic activation. The applicant will also examine the amine effects in cellular level, by live-imaging of downstream neuron activity with sensor protein cameleon. After identifying the amine effects, the applicant will start to dissect aminergic system with powerful genetics of C. elegans, which will provide a good starting point for further studies in future. This project for the first time allows us to examine the dynamic aspects of genetically-dissectable aminergic system, so it will contribute much to understanding aminergic system and also to European excellence in this promising and competitive field of C. elegans neurobiology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- natural sciences chemical sciences organic chemistry amines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-2-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
W1B 1AL LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.