Objective
Trafficking pathways in eukaryotes, their regulatory mechanisms as well as the molecular machinery involved are relatively well understood. However, the underlying genetic regulation has been largely overlooked. The question how cells adapt to various trafficking requirements, and to which extent this regulation is transcriptionally controlled, is of great importance to the field of cell biology and development. In this project, I want to address this question using Arabidopsis seed storage protein trafficking. Late in embryogenesis, large quantities of storage proteins are transported into a novel type of organelle, the storage vacuole. This process is most likely transcriptionally regulated, as it occurs only during this stage of development. Recently, genes involved in this event have been identified in the host laboratory and other groups. I aim to identify the transcriptional regulation of these in order to decipher common cis-regulatory elements, their transcription factors and/or epigenetic regulators. The identified regulators will be first analyzed for functional significance in storage vacuole trafficking. Further analyses will shed light on the fundamental question whether all these responses are developmentally programmed, or whether cells can actually sense their current transport requirements. The proposal is, to my knowledge, the first specifically aimed at the interface between transcriptional control and a cell biological phenomenon. Thus, the proposed project will not only be of interest to plant storage protein trafficking, but also lead to a better understanding of the genetic regulation of plant protein trafficking in general and even other eukaryotic systems, exploring potentially conserved mechanisms. Eventually, identifying the main regulators of storage protein trafficking may also enable altering the storage capacity in vegetative tissues, a trait much sought after in applied plant research to utilize crop plants as biofactories.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- natural sciences biological sciences developmental biology
- agricultural sciences agriculture, forestry, and fisheries agriculture
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.