Obiettivo Curative therapies still do not exist for most CNS diseases but gene therapy is a promising new approach. We propose that it will be possible to modify brain function and pathophysiology by targeted delivery of specific curative factors to selected populations of brain cells that are affected by disease. This opens the door for effective treatment regimes, which can be tailored to individual patients needs. However, currently available gene transfer vectors have limitations regarding safety and efficacy, as they do not allow for targeting of specific populations of neurons or glia or regulation of transgene expression. The NEUGENE consortium has been founded by leading European scientists from academia and industry to overcome these limitations. The consortium will develop Adeno-associated virus (AAV) and Lentivirus (LV)- based tools for targeted and regulated gene transfer into different populations of CNS cells. The consortium will provide a selection of vectors that are optimized for different therapeutic approaches, e.g. regulated expression of neurotrophic factors or manipulation of neurotransmitter synthesis in specific neurons. NEUGENE has three major goals:1) targeting gene transfer vectors to specific populations of neurons and glia, by transcriptional regulation and miRNA-mediated de-targeting and by exploiting the cell-specific tropism of novel types of viral vectors, 2) tight control over expression levels of therapeutic genes by using regulated systems based on different principles, and 3) establishing the safety of the novel vector tools. NEUGENE will verify the functional efficacy of the novel CNS gene transfer tools in a well-established animal model of Parkinson's Disease (PD). This disorder affects over 1.000.000 Europeans and is increasing in prevalence with the aging population. Importantly, principles and mechanisms developed and evaluated within the consortium will also be of direct relevance for gene therapy of many other brain disorder. Campo scientifico medical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesbasic medicineneurologyparkinson Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH-2007-1.4-5 - Gene therapy tools targeting the central nervous system Invito a presentare proposte FP7-HEALTH-2007-B Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS Contributo UE € 690 800,00 Indirizzo Robert-Koch-Strasse 40 37075 Goettingen Germania Mostra sulla mappa Regione Niedersachsen Braunschweig Göttingen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Christiane Hennecke (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto MAX IV Laboratory, Lund University Svezia Contributo UE € 700 800,00 Indirizzo Paradisgatan 5c 22100 LUND Mostra sulla mappa Regione Södra Sverige Sydsverige Skåne län Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Eva Nordin (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE Regno Unito Contributo UE € 300 000,00 Indirizzo EGHAM HILL UNIVERSITY OF LONDON TW20 0EX Egham Mostra sulla mappa Regione South East (England) Surrey, East and West Sussex West Surrey Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Jenny Febry (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Francia Contributo UE € 756 000,00 Indirizzo RUE LEBLANC 25 75015 PARIS 15 Mostra sulla mappa Regione Ile-de-France Ile-de-France Paris Tipo di attività Research Organisations Contatto amministrativo Olivier Leroy (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Svizzera Contributo UE € 452 400,00 Indirizzo BATIMENT CE 3316 STATION 1 1015 Lausanne Mostra sulla mappa Regione Schweiz/Suisse/Svizzera Région lémanique Vaud Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Patrick Aebischer (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato OXFORD BIOMEDICA (UK) LIMITED Regno Unito Contributo UE € 100 000,00 Indirizzo OXFORD SCIENCE PARK MEDAWAR OX4 4GA OXFORD Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Peter Nolan (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
