Objective TREAT-OA will address the need for better treatment and diagnostics for osteoarthritis (OA) - the most common cause of disability in Europe. Currently there are no drugs that can cure, reverse or halt the disease. Nor are there yet reliable clinical biochemical markers for diagnosis or prognosis which is an impediment to the management of OA, costs of therapeutic trials and the development of disease modifying drugs. TREAT-OA represents a large-scale collaborative, integrated, trans-disciplinary project utilising a resource of 28,000 OA phenotyped subjects with available genome-wide association scan data as well as leading basic science laboratories and technologies. This is the largest study of its kind that will address the generalisability and utility of genetic and biochemical risk factors throughout the EU. The key objectives of TREAT-OA are to: 1 Identify genes and biochemical markers consistently associated with risk and progression of OA 2 Use such genes to further our understanding of the molecular pathways involved in disease aetiology 3 Analyze pathways to identify targets for pharmacological intervention 4 Develop transgenic animal laboratory OA model systems . 5 Develop a panel of genetic and biochemical diagnostics for risk and progression of OA 6 Disseminate results from this extensive research at large and use results and technologies for training within the EU TREAT-OA will help develop European clinical and scientific excellence in the diagnosis and treatment of OA. The novel pathways in disease aetiology discovered will translate into novel drug targets and protein therapeutics for OA. The development of in vitro and in vivo assays will provide a comprehensive technology platform enabling the discovery and development of disease modifying drugs for OA. TREAT-OA will also make a major impact on the disease via a diagnostic panel of genes and biochemical markers for selecting severe cases and rapidly progressing individuals. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteins Keywords ENU mutagenesis animal models for drug screening biomarkers diagnosis genome-wide association scan in vitro assays osteoarthritis translational research treatment Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.4.5-1 - Osteoarthritis Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator KING'S COLLEGE LONDON EU contribution € 3 113 787,90 Address STRAND WC2R 2LS London United Kingdom See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Paul Labbett (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 1 635 910,40 Address WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Edward Gibbs (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 513 900,00 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Jan Willem Te Ronde (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ACADEMISCH ZIEKENHUIS LEIDEN Netherlands EU contribution € 821 946,75 Address ALBINUSDREEF 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Liesbeth Dorama (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 1 673 700,00 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Maria Vereeken (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SYNARC SAS France EU contribution € 999 275,00 Address RUE DE MONTBRILLANT 16 69003 LYON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrick Garnero (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TIGENIX NV Participation ended Belgium EU contribution € 628 036,95 Address ROMEINSE STRAAT 12/2 RESEARCH PARK HAASRODE 1724 3001 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Luc Dochez (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PANEPISTIMIO IOANNINON Greece EU contribution € 474 780,00 Address PANEPISTEMIOYPOLE PANEPISTEMIO IOANNINON 45110 Ioannina See on map Region Βόρεια Ελλάδα Ήπειρος Ιωάννινα Activity type Higher or Secondary Education Establishments Administrative Contact George Papageorgiou (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISLENSK ERFDAGREINING EHF Iceland EU contribution € 935 720,00 Address STURLUGOTU 8 101 Reykjavik See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gudmundur Einarsson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW Netherlands EU contribution € 539 740,00 Address KLOVENIERSBURGWAL 29 HET TRIPPENHUIS 1011 JV AMSTERDAM See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Don Van Velzen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ARCARIOS Belgium EU contribution € 587 863,00 Address AGORALAAN A BIS 3590 DIEPENBEEK See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Guido Maertens (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
