Objectif IMECS is a proposal of the FLUSECURE network aimed at combating the threat of new and re-emerging forms of highly pathogenic influenza in its first stages of a disease by identifying mechanisms of protection that are essential for a solid immune response to avian influenza. IMECS is uniquely featured by correlating research in humans directly to protection from influenza. The IMECS initiative was introduced since the recent H5N1 avian influenza vaccine trials results have shown limited success in inducing a protective immune response as compared to the standard human influenza vaccines. This despite large investments and multiple vaccine formulations tested. These results make clear that the mechanisms of immunity for avian influenza are inherently different from those for human/seasonal influenza. The IMECS initiative aims to elucidate these mechanisms and aims to provide essential knowledge for development of breakthrough pandemic vaccines as a result. The initiative thereto boosts the development of AI-correlates of protection for the clinical screening of vaccine candidates in healthy adults and in different target groups, the origin of subclinical AI infection in humans, as well as a research programme for the screening of vaccine candidates in vitro. The following research objectives are pursued: - Determining the basis of the homologous and non-homologous mechanisms of protection for avian influenza; - Determine the mechanisms of protection in specific target groups, including infants and the elderly; - Determining the AI-specific response after vaccination in clinical trial studies. IMECS combines the knowledge of leading European universities and research centres. The multidisciplinary consortium has the resources, skills and knowledge to realize the objectives of this collaborative research project.The consortium consists of 6 partners and two subcontractors from five different European countries and one disease endemic country (SICA) Champ scientifique medical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenzamedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Mots‑clés Homologous Homologous non-homologous mechanisms of protection influenza target-groups correlates of protection correlates of protection influenza target-groups mechanisms of protection non-homologous Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH-2007-2.3.3-2 - Identifying immunological mechanisms of protection for influenza vaccines Appel à propositions FP7-HEALTH-2007-A Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU Contribution de l’UE € 365 226,00 Adresse Antonie Van Leeuwenhoeklaan 9 3721 MA Bilthoven Pays-Bas Voir sur la carte Région West-Nederland Utrecht Utrecht Type d’activité Research Organisations Contact administratif Marjon Hartwigsen (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (7) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire VIEN VE SINH DICH TE TRUNG UONG Viêt Nam Contribution de l’UE € 150 584,00 Adresse YERSIN STREET HAI BA TRUNG 1 1000 HANOI Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Duc Anh Dang (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée TERVEYDEN JA HYVINVOINNIN LAITOS Finlande Contribution de l’UE € 492 975,00 Adresse MANNERHEIMINTIE 166 00271 Helsinki Voir sur la carte Région Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Type d’activité Research Organisations Contact administratif Jaakko Penttinen (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ACADEMISCH ZIEKENHUIS LEIDEN Pays-Bas Contribution de l’UE € 399 750,00 Adresse ALBINUSDREEF 2 2333 ZA Leiden Voir sur la carte Région West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Type d’activité Higher or Secondary Education Establishments Contact administratif Sonja Croes (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA Suisse Contribution de l’UE € 388 379,00 Adresse VIA FRANCESCO CHIESA 5 6500 Bellinzona Voir sur la carte Région Schweiz/Suisse/Svizzera Ticino Ticino Type d’activité Research Organisations Contact administratif Fosca Bognuda (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ISTITUTO SUPERIORE DI SANITA Italie Contribution de l’UE € 240 845,00 Adresse Viale Regina Elena 299 00161 Roma Voir sur la carte Région Centro (IT) Lazio Roma Type d’activité Research Organisations Contact administratif Rosa Maria Martoccia (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée FONDAZIONE ANDREA CESALPINO* Italie Contribution de l’UE € 111 030,00 Adresse Via Sicilia 169 00187 ROMA Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Luigino Mangiapelo (Mr.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée MINISTERIE VAN VOLKSGEZONDHEID, WELZIJN EN SPORT Participation terminée Pays-Bas Contribution de l’UE € 648 498,00 Adresse PARNASSUSPLEIN 5 2500 EJ Den Haag Voir sur la carte Région West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Type d’activité Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contact administratif Ernst Soethout (Mr.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée
