Objective Early detection accomplished through an efficient screening programme remains the most promising approach to improve the long-term survival of cancer patients. Therefore there is a pressing need for the development of biomarkers, which detect the early changes for cancers where clinical symptoms only appear when the cancer has progressed, and treatment is ineffective. Our proposal, which addresses this problem at the European level, combines two unique features: i) large unique collections of sera with the potential for evaluation of diagnostic serum biomarkers with high statistical power, and ii) a novel technological approach involving specific immuno-detection of cancer-associated Post-Translationally Modified (PTM) glycoproteins in serum and of auto-antibodies to these glycoproteins. Glycosylation of proteins is one of the most abundant and complex forms of post translation modifications and the most important for the cell surface and secreted proteomes. O-glycosylation (O-PTM) is always altered in carcinomas, creating novel O-PTM epitopes which induce auto-antibodies. Our Main Objectives are therefore to:- 1.Use a novel glycopeptide microarray technology to identifiy, evaluate and validate an O-PTM auto-antibody signature as an early diagnostic biomarker, focusing on breast, ovarian, pancreatic and lung cancers. 2. Develop and validate novel ELISA-type assays for cancer specific glycoforms of the MUC1 and MUC16 glycoproteins (targets of current serum biomarker assays). The project brings together a Consortium with participants from 5 member States to fully exploit the potential of the unique serum banks at a European level by A. Integrating the expertise of world leaders in Glycobiology with Cancer Physicians and experts in biomarker assays. B. Establishing a functional interaction between Academic groups and Commercial enterprises committed to improving cancer therapy and diagnosis. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesclinical medicineoncologylung cancer Keywords Auto-antibody signature Cancer Cancer associated glycoforms Early diagnosis Glycopeptide microarrays Glycoproteomics O-linked glycosylation Post-translational modification Serum biomarkers Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.4.1-4 - Novel cancer screening methods HEALTH-2007-2.4.1-2 - Translating clinical ’omics’-technology (genomics, proteomics, metabolomics) into innovative cancer biomarkers aiding in early diagnosis, prognosis and treatment selection of cancer patients Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator KING'S COLLEGE LONDON EU contribution € 615 216,00 Address STRAND WC2R 2LS London United Kingdom See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Paul Labbett (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all KOBENHAVNS UNIVERSITET Denmark EU contribution € 424 100,00 Address NORREGADE 10 1165 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Administrative Contact Ivan Kristoffersen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TRANSGENE SA France EU contribution € 137 000,00 Address BOULEVARD GONTHIER D ANDERNACH PARC D INNOVATION 67400 Illkirch-Graffenstaden See on map Region Grand Est Alsace Bas-Rhin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Philippe Poncet (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON EU contribution € 371 137,00 Address GOWER STREET WC1E 6BT LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Michael Browne (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KLINIKUM DER UNIVERSITAET ZU KOELN Germany EU contribution € 374 100,00 Address Kerpener Strasse 62 50937 Koeln See on map Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Jutta Landvogt (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THYMED GMBH Germany EU contribution € 304 000,00 Address Mikroforum Ring 2 55234 WENDELSHEIM See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Peter Trinder (Dr.) Links Contact the organisation Opens in new window Total cost No data IPATIMUP - INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP Portugal EU contribution € 264 000,00 Address RUA JULIO AMARAL DE CARVALHO 45 4200 135 Porto See on map Region Continente Norte Área Metropolitana do Porto Activity type Research Organisations Administrative Contact Ana Sofia Silva (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ANTIGONE LTD United Kingdom EU contribution € 109 800,00 Address Highpoint Business Village YN24 8DH ASHFORD See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Joyce Taylor-Papadimitriou (Prof.) Links Contact the organisation Opens in new window Total cost No data ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE United Kingdom EU contribution € 248 800,00 Address EGHAM HILL UNIVERSITY OF LONDON TW20 0EX Egham See on map Region South East (England) Surrey, East and West Sussex West Surrey Activity type Higher or Secondary Education Establishments Administrative Contact Susan Angulatta (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
