Objective
Astroglial cells are now recognized as active elements in the brain that sense and integrate synaptic signals and, by releasing gliotransmitters, regulate synaptic efficacy and cerebral blood flow. Despite accrued knowledge, many fundamental aspects of neuron-astroglia partnerships remain open, or have been poorly addressed in a functional context in vivo. For example, does astroglia heterogeneity reflect distinct functions? How do astroglial and neuronal networks interact locally and temporally? How does disruption of neuron-glia interactions contribute to brain disorders? Leading European research groups in the field have gathered in NeuroGLIA to address such questions using a multi-disciplinary approach, including transgenic astroglia-subtype specific mice, electrophysiology and high resolution laser scanning microscopy in vitro and in vivo (including awake mice). This will enable the consortium: i) to verify the potential of activated astroglia to signal back to neurons rapidly; ii) to define the spatial-temporal dynamics of neuron–astroglia reciprocal signalling; iii) to clarify the specific function of different astroglial subtypes in modulation of neuronal excitability and transmission, and in the control of neurovascular coupling. NeuroGLIA will also investigate how dysfunction of neuron-astroglia signalling contributes to the pathogenesis of brain disorders, focussing on epilepsy. In animal models of epilepsy, astroglial activity will be analyzed with respect to initiation, maintenance and cessation of epileptiform activity, also in relation to blood flow changes and activation of inflammatory pathways. Importantly, access to living tissue from epilepsy patients, allows NeuroGLIA to investigate neuron-astroglia interactions and its dysregulation in the human brain. NeuroGLIA is thus in the privileged position to unravel fundamental mechanisms of neuron-astroglia signalling in health and disease, opening new perspectives for specific therapeutic strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine neurology epilepsy
- natural sciences physical sciences optics microscopy
- natural sciences physical sciences optics laser physics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2007-A
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
53127 Bonn
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.