Objective
Mismatch2model: Characterization and quantitative modeling of DNA mismatch repair and its role in the maintenance of genomic stability and cancer avoidance DNA mismatch repair (MMR) plays a crucial role in the maintenance of genomic stability. In both bacteria and eukaryotes, the loss of mismatch repair gives rise to a mutator phenotype. In hereditary non-polyposis colon cancer (HNPCC) families, germline mutations in one MSH2, MSH6 or MLH1 allele predispose to cancer of the colon, endometrium, ovary and other organs. HNPCC is the most frequent form of familiar cancer. In the mismatch2model project we adopt and exploit a systems biology approach in which we combine Europe’s expertise in DNA mismatch repair with sophisticated multidisciplinary technology and expertise in quantitative modeling in order to describe this DNA repair process at different levels of complexity. The multidisciplinary consortium will have the following tasks that relate directly to the topics raised in Call HEALTH 2.1.2.5: - Gather quantitative and structural data sets describing the principal steps of DNA mismatch repair - Integrate and analyze structural and functional data obtained from single molecule and bulk studies - Develop mathematical models for single and/or multiple steps of the MMR pathway - Perform analyses at different levels of complexity: from recognition of the mismatch through repairosome assembly to in vivo function - Combine the well-understood MMR E.coli model system with the cancer-protective human system The combination of the individual strengths of the multidisciplinary groups involved in this program ensures that significant progress will be made towards the understanding of this complex process.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology colorectal cancer
- natural sciences biological sciences genetics mutation
- natural sciences mathematics applied mathematics mathematical model
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2007-B
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3015 GD Rotterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.