Objectif A common trait to disorders such as type 2 diabetes or obesity is the development of insulin resistance. There is evidence indicating the existence of a bidirectional cross-talk between insulin signalling and mitochondrial function that may be relevant for the pathogenesis of those disorders. Based on this, MITIN main goal is to identify novel mitochondrial-dependent mechanisms responsible for the development of insulin resistance. This will be done by the use of technologies of Systems Biology and the generation of computer-based tools that will permit the study of complex biological systems that integrate different regulatory networks. For the global visualization and interpretation of the “insulin signalling/mitochondria” complex system we plan to develop a computational framework that will store and integrate all possible data for each of the subsystems, both currently available data and data generated within the project by transcriptomics and lipidomics analysis. This will allow the prediction of functional associations and interactions between both processes, which will be tested under specific hypothesis-driven studies in mammalian cells, mice and Drosophila. By using a Systems Biology approach and investigating how different perturbations modulate cell transcriptomes, and lipidomes, we aim to identify integrated homeostatic responses involving the insulin signalling network and the mitochondria networks. Validation of some of the strongest associations detected by virtue of the integrated systems biology of insulin signalling/mitochondria will generate high value targets of use in therapy against Complex Diseases such as diabetes, obesity, or pathophysiological traits of the Metabolic Syndrome. Besides, computer-based tools generated in the project will be applicable to the analysis of the mechanisms that trigger other Complex Diseases. Champ scientifique medical and health sciencesclinical medicineendocrinologydiabetesmedical and health scienceshealth sciencesnutritionobesitynatural sciencescomputer and information sciencessoftwaresoftware applicationssimulation software Mots‑clés Complex Diseases Systems Biology bioinformatics diabetes insulin resistance insulin signalling mitochondrial function profiling technologies Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH-2007-2.1.2-5 - Multidisciplinary fundamental genomics and molecular biology approaches to study basic biological processes relevant to health and diseases Appel à propositions FP7-HEALTH-2007-B Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) Contribution de l’UE € 678 700,00 Adresse CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA 08028 Barcelona Espagne Voir sur la carte Région Este Cataluña Barcelona Type d’activité Research Organisations Contact administratif Adriana Grosu (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire BARCELONA SUPERCOMPUTING CENTER CENTRO NACIONAL DE SUPERCOMPUTACION Espagne Contribution de l’UE € 403 931,00 Adresse CALLE JORDI GIRONA 31 08034 Barcelona Voir sur la carte Région Este Cataluña Barcelona Type d’activité Research Organisations Contact administratif Mercè Calvet (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée TEKNOLOGIAN TUTKIMUSKESKUS VTT Finlande Contribution de l’UE € 625 336,00 Adresse TEKNIIKANTIE 4 A 02044 VTT ESPOO Voir sur la carte Type d’activité Research Organisations Contact administratif Katri Kokkila (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée THE UNIVERSITY OF LIVERPOOL Royaume-Uni Contribution de l’UE € 471 633,00 Adresse BROWNLOW HILL 765 FOUNDATION BUILDING L69 7ZX Liverpool Voir sur la carte Région North West (England) Merseyside Liverpool Type d’activité Higher or Secondary Education Establishments Contact administratif Jane Cloke (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Royaume-Uni Contribution de l’UE € 465 153,00 Adresse TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Voir sur la carte Région East of England East Anglia Cambridgeshire CC Type d’activité Higher or Secondary Education Establishments Contact administratif Dawn Edwards (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Allemagne Contribution de l’UE € 311 737,00 Adresse IM NEUENHEIMER FELD 280 69120 Heidelberg Voir sur la carte Région Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Type d’activité Research Organisations Contact administratif Bettina Crispin (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
