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Content archived on 2024-06-18

Characterization of Reactive Oxygen Species as Innate Immune System Mediators that Control Inflammation

Objective

Biomedical research in the post genomic era will depend on the establishment of collaborative efforts between clinical and preclinical researchers, combining bedside medical research with experimental science. This project stems from initial gene expression studies on immune compromised patients with severe inflammatory disorders. The results allowed us to generate the hypothesis that reactive oxygen radicals are key anti-inflammatory agents in the immune system. We also embrace the novel idea that it is possible to stimulate an innate immune response without exciting harmful inflammation and moreover, that it is possible to identify molecular regulators as potential therapeutic targets that allow such an immune response. The proposed project will be multidisciplinary, incorporating old and new technologies in both the wet and dry lab environments that combine aspects of immunology, cell biology, bioinformatics and clinical microbiology. It will constitute the first comprehensive study of the role of oxygen radicals in inflammation and immunity outside the traditionally described roles of radicals in oxidative microbial killing and neutrophil apoptosis. In addition, it will highlight a novel set of immune regulators with therapeutic potential and provide a template for future biology-based drug discovery platforms that originate in the clinic.

Fields of science (EuroSciVoc)

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2007-4-2-IIF
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IIF - International Incoming Fellowships (IIF)

Coordinator

GOETEBORGS UNIVERSITET
EU contribution
€ 178 454,93
Address
VASAPARKEN
405 30 Goeteborg
Sweden

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Region
Södra Sverige Västsverige Västra Götalands län
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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