Objective
"RNA interference (RNAi) induces gene silencing and is involved in host responses to pathogens. Faced with the bacterium Serratia (S.) marcescens, Caenorhabditis (C.) elegans responds with a behavioural response (""lawn avoidance""). Since mutation of the RNAi gene rde-4 impairs lawn avoidance, RNAi seems to be involved. S. marcescens infection leads to upregulation of antimicrobial peptide genes in C. elegans. Our hypothesis is that RNAi is involved in controlling this transcriptional response. This project aims to characterise the role of RDE-4 and other RNAi pathway components in the avoidance behaviour and the transcriptional response of C. elegans. This will be achieved by identifying putative RNA-protein-complexes formed with RDE-4 upon S. marcescens infection. Concerning the role of RNAi in controlling defence gene expression, it will be investigated if two antimicrobial peptide genes, nlp-29 and cnc-2, are regulated by microRNAs (miRNA). miRNA arrays will be used to investigate which of the annotated miRNAs are regulated by S. marcescens infection. Candidate miRNA genes and their targets will be characterised. The multidisciplinary project “MicroDetect” will support competence diversification and career development of the fellow. Its research training objectives are scientific and technical. The fellow wishes to extend her knowledge in molecular biology and learn techniques required to use C. elegans as model system to study host-pathogen interactions. This will be achieved by training through research. The fellow will extend her complementary skills in project management, presentation, manuscript preparation and collaboration building through implementation of the project and mentoring by the supervising scientist. By offering scientific and complementary training this project will support the fellow in attaining a leading position. The Community will benefit from the strengthening of the research field by gaining a highly qualified independent researcher."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences biochemistry biomolecules
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences molecular biology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.