Fiber optic activation of serotonergic terminals during olfactory discrimination

Projektinformationen

FAST

ID Finanzhilfevereinbarung: 220098

Abgeschlossenes Projekt

Startdatum 16 Oktober 2008

Enddatum 15 Oktober 2010

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 92 077,94

EU-Beitrag € 92 077,94

Koordiniert durch

FUNDACAO CALOUSTE GULBENKIAN
Portugal

Ziel

"In the central nervous system, 5-hydroxytryptamine (5-HT, or serotonin) acts as a neuromodulator and is synthetized by a specific population of neurons. 5-HT is released in nearly all subdivisions of the CNS and is involved in a wide array of brain functions as well as in several disorders. Although current hypotheses regarding the role of central 5-HT remain wide-ranging, a prominent view has progressively emerged from previous studies. A primary function of 5-HT might be to dampen sensory information processing while facilitating motor output. This ""sensorimotor gating"" hypothesis is supported by indirect evidence and has never been tested directly. This proposal aims at investigating the influence of 5-HT on olfactory performance. By using mice expressing a recently developed light-gated cation channel (Channelrhodopsin-2) in serotonergic neurons, we will be able to excite serotonergic afferents to the olfactory bulb through a fiber optic interface. Using this innovative method, we will interfere with the native modulation pattern of these afferents during olfactory discrimination. The effects of this manipulation will be assessed directly at the behavioral level. This novel experimental paradigm offers tremendous improvements compared to previous ones and is expected to provide unprecedented insights into the role of central 5-HT in sensory processing."

Wissenschaftliches Gebiet

• natural sciences › biological sciences › neurobiology
• engineering and technology › materials engineering › fibers
• social sciences › sociology › social issues › social inequalities
• natural sciences › physical sciences › optics › fibre optics
• natural sciences › computer and information sciences › data science › data processing

Schlüsselbegriffe

• behavioral neuroscience
• central nervous system
• channelrhodopsin
• neuromodulation
• neurophysiology
• olfaction
• sensory processing
• serotonin

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2007-2-1-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

FUNDACAO CALOUSTE GULBENKIAN

Kontakt Verwaltung

Zachary Mainen (Dr.)

• EU-Beitrag: € 92 077,94
• Adresse: AVENIDA BERNA 45A ; 1067-001 LISBOA ; Portugal
• Region: Continente › Área Metropolitana de Lisboa › Área Metropolitana de Lisboa
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten