Objetivo Molecular biology has shown that most phenotypes are affected by complex, interacting gene networks. Yet, evolutionary biologists and population geneticists often assume very simple genetic architectures where genes act more of less independently of each other. These assumptions are made for conceptual clarity and are partially justified through statistical definitions of gene effects that capture the main effects of alleles as averages over many complex interactions. Still, recent research has revealed many systematic patterns of epistasis and pleiotropy with population genetic effects that should not be ignored. This makes a detailed understanding of genetic architecture important for many questions in evolutionary biology, including the basis of evolvability, and also instrumental for many questions in animal and crop improvement, including our ability to predict selection limits and to avoid unwanted side effects of artificial selection. The philosophy of this project is to develop methods that yield operational measurements of dynamically relevant parameters. A serious problem is the study of genetic architecture has been that many of the parameters in use are not derived from process models, epistatic variance components being the most obvious example. For this reason, it is necessary to combine the statistical models with process models to ensure a general understanding of the meaning of estimators. Ámbito científico natural sciencesbiological sciencesevolutionary biologyagricultural sciencesagriculture, forestry, and fisheriesagriculturenatural sciencesmathematicsapplied mathematicsstatistics and probabilityhumanitiesphilosophy, ethics and religionphilosophynatural sciencesbiological sciencesmolecular biology Palabras clave Animal and Plant Breeding Biodiversity Population genetics Quantitative Genetics Statistics Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Convocatoria de propuestas FP7-PEOPLE-2007-2-1-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador UNIVERSITETET I OSLO Aportación de la UE € 189 689,90 Dirección PROBLEMVEIEN 5-7 0313 Oslo Noruega Ver en el mapa Región Norge Oslo og Viken Oslo Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Maren S. Rasch Onsrud (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
