Objective
Oomycete and fungi deliver a variety of effector proteins into plant host cells to suppress defense responses and enable successful colonization. Some of these effectors are secreted into host apoplast where they target plant enzymes to inhibit their activities. Others are secreted into the host cytoplasm and nucleus where they manipulate host immunity. The mechanisms involved in transport of oomycete and fungal effectors and host defense manipulation remain unclear. One key approach to unraveling effector function is to find their host cell targets and derive hypotheses about the effector mode of action. Phytophthora infestans offers an excellent system for applying this strategy. The objective of this proposal is to determine the target proteins of the recently identified family of P. infestans effectors to elucidate their biological function. Our hypothesis is based on the fact that P. infestans secretes a diverse set of proteins that target host proteins to suppress host responses and facilitate infection. This hypothesis is supported by preliminary data that demonstrated that P. infestans RXLR type efector protein, AVR3a, is delivered into the host cytoplasm and suppresses hypersensitive cell death mediated by another Phytophthora protein INF1. In this proposal, we will focus on (i) identification of host interactors of P. infestans cytoplasm and nuclear localized effector proteins; (ii) identification of the functions of host effector targets using a VIGS approach in tomato plants. Considering that none of the host translocated fungal and oomycte effectors have been assigned a precise biological function, the proposed research will provide a significant contribution to understanding how filamentous pathogen effectors promote disease. Also, this proposal will provide insights into key molecular processes regulating susceptibility to an economically important pathogen.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology mycology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NR47UH Norwich
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.