Objective
Teeth form as appendages of embryonic ectoderm and their development is regulated by similar mechanisms to other ectodermal organs like hairs and glands. More than 300 genes are currently known to be involved in tooth development. However, the mechanisms that regulate gene expression at specific times and locations are only partially understood. The most interesting open questions concern the mechanisms of the initial acquisition of organ specificity and the regulation of stem cells. microRNAs (miRNAs) constitute a class of short regulatory RNAs that control gene expression post-transcriptionally. Their involvement in the genetic network regulating tooth development and dental stem cells has not been explored yet. This project aims to identify the miRNAs involved in the development of teeth as well as some other ectodermal organs and dental stem cells. The identification and analysis of the roles of miRNAs and their mRNA targets will be performed using bioinformatics linked to classical developmental/molecular/cell biology methods as well as novel sophisticated technologies such as miRNA microarray analysis and inhibition studies with tissue electroporation and LNAs. The results are expected to contribute to the development of novel clinical applications in the field of tissue regeneration and stem cells. The project will join an experienced researcher from ectodermal organ formation field and an internationally well-known group in tooth development to enhance European competitiveness and excellence in developmental and regenerative biology. This project gives the opportunity to increase the researcher's independency and to work in a very timely area. He will learn new skills, such as microarrays and miRNA technologies and acquire training in important bioinformatic tools, all important for the future career. In addition, this project will help him to develop an international scientific network.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences cell biology
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences genetics RNA
- natural sciences chemical sciences electrochemistry bioelectrochemistry electroporation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-2-1-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00014 HELSINGIN YLIOPISTO
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.