Skip to main content
European Commission logo print header

Development of a model of in vitro endochondral ossification with neovascularisation

Obiettivo

The aim of this proposal is to develop an in vitro model of endochondral ossification combined with neovascularisation in order to develop treatments for musculoskeletal ailments and to enable us to better understand the processes leading to tissue formation and disease processes, such as osteoarthritis. The process of endochondral ossification is that by which bone is formed not directly but by first developing cartilage, which is subsequently mineralised and vascularised. These two processes are intimately linked. This project will use adult human marrow stromal cells to induce bone formation via chondrogenesis and chondrocyte hypertrophy as occurs with endochondral ossification. Neovascularisation will also be induced separately using the same cell and scaffold source. These constructs will then be combined in a truly novel approach to understand the role of vessel invasion in bone and cartilage formation. Generation of a viable vascularised bone construct will also take place. In the coming years, with an increasing demographic trend towards an older population in Europe and worldwide, there is a serious socioeconomic need for the development of new treatments for musculoskeletal ailments. One of the problems with current tissue engineering approaches to these problems is a lack of basic understanding of the complex process underway in tissue repair in vivo. This model will serve two purposes. Firstly it will deepen this understanding and secondly, it will offer several potentially suitable treatment options for bone and cartilage repair.

Invito a presentare proposte

FP7-PEOPLE-2007-2-1-IEF
Vedi altri progetti per questo bando

Coordinatore

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Contributo UE
€ 119 575,67
Indirizzo
DR MOLEWATERPLEIN 40
3015 GD Rotterdam
Paesi Bassi

Mostra sulla mappa

Regione
West-Nederland Zuid-Holland Groot-Rijnmond
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Gerjo Van Osch (Dr.)
Collegamenti
Costo totale
Nessun dato