Objective
The focus of this proposal is to characterize the functions of novel components of the flower development gene regulatory network in Arabidopsis, using various genomic approaches. The proposed work will target: (1) novel coding small open reading frames (sORFs) detected in intergenic regions; (2) novel or uncharacterized microRNAs and protein-coding genes potentially implicated in flower development (by previous genome-wide expression analyses); and (3) selected transcription factors known to participate in the process. Extensive genetic analyses of flower development in Arabidopsis and Antirrhinum have led to the identification of key regulatory genes of the process. Most of these regulators code for transcription factors, and microarray analyses have revealed the existence of a complex transcriptional network underlying the floral development process. Yet, many components of this network likely still remain to be identified (belonging to classes of genes that have been more untractable by classic genetic and molecular biology methods, such as sORFs and miRNAs); and many protein coding genes that likely participate in the process remain functionally uncharacterized. In addition, targets of the known regulators are still largely ill-defined. The objectives of the project are: (1) to conduct expression profiling experiments aimed at identifying novel sORFs that may participate in flower development, and at understanding their roles; (2) to begin to elucidate the functions of novel, uncharaterized components of the regulatory network (sORFs, miRNAs, and protein-coding genes) through various reverse-genetic approaches; and (3) to use novel genomic methods, in particular the recently developed ChIP-Seq approach, to identify target genes of known regulators. While these objectives are diverse in the nature of their molecular targets and in the experimental methods used, their combination is required for a deeper understanding of developmental regulatory networks.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences molecular biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-3-IRG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08193 Cerdanyola Del Valles
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.