Objective
45% of the human genome is made of repeated DNA, and some types can be mobilized within the genome (mobile DNA). LINE-1 or L1 is the only autonomous active mobile DNA within the human genome, with 500.000 copies per haploid genome (~17% of the genome). Overall, L1 is responsible for ~30% of our genome. Due to its activity and number in the genome, the impact that L1 has and have on the genome is notable. L1 mobility can result in several human diseases (due to insertions within genes) and can also participate in gene creation. L1 mobility is an active process in the human population, and we have recently demonstrated that human embryonic stem cells (hESCs) express L1 and can accumulate new copies of L1. As a result, some of these new copies will be transmitted to newborn individuals. Recently, it has been demonstrated that L1 is active in several somatic adult cell types. These are by definition cell types that will not disperse new L1 copies in the population. As a consequence, these results are a paradigm for the notion of L1 as a piece of “selfish DNA”, which is in the genome solely by its ability to replicate within the genome. In the present application, we will determine the level of expression and activity of L1 elements in several somatic stem cell types (neuronal, mesenchymals, and hematopoietic) in order to inspect the impact and mosaicism generated by L1 in somatic human tissues. The determination of the somatic impact of LINE-1 will shed light in several biological processes: from its role in the Central Nervous System, to its implication in several human diseases (is LINE-1 involved in the progression of human diseases as cancer?). Furthermore, its study will allow the design of therapeutic approaches in order to control its activity in somatic tissues. It is worth mentioning that the somatic activity of LINE-1 could be involved in several human diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences genetics DNA
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-3-IRG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
41092 Sevilla
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.