Objetivo Malaria is a complex disease, dependent on multiple host/parasite/vector interactions. This tripartite system offers numerous opportunities for disease-preventing interventions, but also creates robustness that undercuts ‘magic bullet’ expectations. Our interdisciplinary TransMalariaBloc will approach the challenge of malaria control in the field from this perspective. It utilizes the enormous recent advances in our molecular understanding of the three implicated organisms without prejudicing which targets or process will prove most suitable to transmission blocking (TB). In a feedback loop of experimentation and modeling, we will address the potential and actual impact of TB drugs and remedies which supplied to human hosts, can block transmission from an infected bloodmeal; TB vaccines which elicit human antibodies to antigens essential for transmission; and immune mosquitoes, genetically modified (GM) to achieve natural or synthetic refractoriness. Recent studies suggest that vector/parasite genotypic interactions determine the success or failure of Plasmodium falciparum to infect mosquitoes. In this perspective, we will assay genome-wide polymorphisms in both parasites and vectors to dissect important genotype*genotype interactions, thus guiding the development of effective TB vaccines, drugs and remedies, and GM mosquitoes. Effectiveness of TB interventions, especially via use of GM mosquitoes, depends on the balance of infection and resistance costs. Components of this balance will be explored, to foresee the dynamics of vectorial competence in mosquito populations and assess the efficacy of TB strategies, as well as guide the development of new targets. Again, interaction between modeling and experimentation will be a powerful combination. This proposal represents an ambitious, but feasible approach, spanning from molecular to population and environmental levels, to optimizing TB interventions for malaria control in endemic areas. Ámbito científico medical and health scienceshealth sciencesinfectious diseasesmalariamedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological scienceszoologyinvertebrate zoology Palabras clave Anopheles Disease Evolution Immunity Infection Interactions Modelling Parasite Plasmodium Vector Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH-2007-2.3.2-9 - Blocking the transmission of malaria: the mosquito vector target Convocatoria de propuestas FP7-HEALTH-2007-B Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Aportación de la UE € 1 190 802,00 Dirección SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON Reino Unido Ver en el mapa Región London Inner London — West Westminster Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Brooke Alasya (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (6) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITA DEGLI STUDI DI CAMERINO Italia Aportación de la UE € 291 470,00 Dirección PIAZZA CAVOUR 19F 62032 Camerino Ver en el mapa Región Centro (IT) Marche Macerata Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Ermanno Pieroni (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos LIVERPOOL SCHOOL OF TROPICAL MEDICINE Reino Unido Aportación de la UE € 299 108,00 Dirección PEMBROKE PLACE L35QA LIVERPOOL 3 Ver en el mapa Región North West (England) Merseyside Liverpool Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Robert Einion Holland (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos IDRYMA TECHNOLOGIAS KAI EREVNAS Grecia Aportación de la UE € 386 840,00 Dirección N PLASTIRA STR 100 70013 Irakleio Ver en el mapa Región Νησιά Αιγαίου Κρήτη Ηράκλειο Tipo de actividad Research Organisations Contacto administrativo Zinovia Papatheodorou (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT Francia Aportación de la UE € 311 688,00 Dirección BOULEVARD DE DUNKERQUE 44 CS 90009 13572 Marseille Ver en el mapa Región Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Tipo de actividad Research Organisations Contacto administrativo Ariel Crozon (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE ET TECHNOLOGIQUE*INSTITUT DE RECHERCHE EN SCIENCES DE LA SANTE Burkina Faso Aportación de la UE € 307 224,00 Dirección B P 7047 03 Ouagadougou Ver en el mapa Tipo de actividad Research Organisations Contacto administrativo Levy Kaboré (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos MAKERERE UNIVERSITY Uganda Aportación de la UE € 206 832,00 Dirección Main Campus 256 Kampala Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Vincent Ssembatya (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos
