Objective The objective of NANOMAGDYE consists in developing tailored biocompatible magneto-optical nanosystems based on magnetic iron oxide nanoparticles. The project will comprise the elaboration of the nanosystems and the characterisation of their structural, optical and magnetic properties. In vitro and in vivo tests will be carried out to test their biocompatibility. The combination of magnetic and optical properties will be achieved through hybrid nanoparticles made of a magnetic iron oxide core on which an organic layer (dye) will be grafted through a dendrimer molecule and a phosphate entity. This grafting strategy will be extended to bubbles on which magnetic nanoparticles will be attached. The grafting sites will be controlled in order to design new geometries and architectures from rings up to submicronic magnetic spheres. Magnetic nanoparticles with monodisperse size between 2 and 100 nm will be elaborated in order to increase the possibility range of achieved properties. The opto-magnetic nanoparticles will be tested in a medical application and a dedicated magneto-optical probe will be fabricated. Current methods for labelling the lymph node system use a dye (vital blue) or radio nuclide injection detected through optical or Gamma probes, respectively, or a combination of both types of markers. Combining optical and magnetic labelling into a single biocompatible nanosystem will provide higher spatial resolution than presently and avoid using ionising radiation to improve patient safety and medical effectiveness. Stabilized submicronic bubbles labelled with the optical-magnetic nanoparticles will play the role of a contrast agent currently used in echography imaging and facilitate the uptake of the iron nanoparticle, and therefore improve node imaging. Fields of science natural sciencesmathematicspure mathematicsgeometryengineering and technologynanotechnologynano-materials Keywords Tailored opto-magnetic nanoparticles for health applications grafting strategies hybrid functionnal nanosystems magnetic bubbles Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2007-2.2-2 - Nanostructured materials with tailored magnetic properties Call for proposal FP7-NMP-2007-SMALL-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS EU contribution € 980 025,00 Address RUE MICHEL ANGE 3 75794 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Denis Fix (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITAT DES SAARLANDES Germany EU contribution € 226 960,00 Address CAMPUS 66123 Saarbrucken See on map Region Saarland Saarland Regionalverband Saarbrücken Activity type Higher or Secondary Education Establishments Administrative Contact Mareike Schmitt (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SOFTEC TECHNOLOGY AND RESEARCH SRL Italy EU contribution € 326 706,00 Address VIA ALBORNOZ 14 40141 40141 See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Piero Chirco (Prof.) Links Contact the organisation Opens in new window Total cost No data MUSZAKI FIZIKAI ES ANYAGTUDOMANYI KUTATOINTEZET - MAGYAR TUDOMANYOS AKADEMIA Hungary EU contribution € 176 400,00 Address Konkoly Thege Miklos ut 29-33 1121 BUDAPEST See on map Activity type Higher or Secondary Education Establishments Administrative Contact Vera Somogyi (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EURORAD 2 6 France EU contribution € 367 716,00 Address Rue Ettore Bugatti, 2 67201 Eckbolsheim See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anne Kazandjian (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 297 301,00 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Carlos Manuel Abad Ruiz (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data