Objective
The research here outlined deals with the relevance of ubiquitination in TGF-beta growth factor signalling. As outlined below (subchapters) TGF-beta signalling is fundamental for embryonic development and for a variety of human pathologies. In particular, recent data showed that tuning TGF-beta signalling is essential for differentiation of pluripotent cells and for cancer and metastasis. The proposal is therefore highly relevant not only scientifically but also for the socio-economic reasons. We will place emphasis of monoubiquitination as a mechanism to regulate protein function, which is a new concept emerging in signal transduction. Multidisiplinarity. As TGF-beta is such a pleiotropic cytokine, the research is highly multidisciplinary, ranging from biochemistry of the Smad4 signal transducer, to identification of new enzymes impinging on Smad4 ubiquitination levels, and how these events ultimately impact on the embryonic development and proliferative behaviour of adult cells. The reason for me to apply to this incoming international fellowship is to linked my specific expertise, that is, the ability to carry out special type of manipulations such as depletion of maternal mRNA in Xenopus oocytes (that are simply not present in Europe) or generation of transgenic frogs (poorly diffused). These technologies will be of help to the characterization of the embryonic phenotype of Smad4 modifying enzymes that are supplied maternally to the conceptus. Being the hosting laboratory a world leader in the TGF-beta signalling and embryonic development field, these expertise will now be able to spread in Europe. My own expertise will therefore integrate with those of the hosting group leading to a mutually beneficial and synergistic approach to a very complex and daring biological problem.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences developmental biology
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-2-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
35122 Padova
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.