Objective
Obesity is the fasted growing health problem in the Western World. In the United States, obesity as cause of preventable mortality (365,000 deaths in the year 2000) will soon overtake tobacco (435,000 deaths) and already has overtaken alcohol consumption (85,000 deaths), infectious diseases (75,000) and motor vehicle crashes (43,000). More important, it is also a problem in children and adolescent, and accordingly, one of the major future health problems. We hypothesize that the reduction of hormones/signals, released or blocked after food intake as nutrition signal, significantly contributes to the feed-back in food intake, and subsequently to the onset in obesity. Accordingly, the focus of this project is the understanding of the contribution of gastro-intestinal peptides to the onset of obesity. It is aimed to identify the most relevant hormones or combinations of hormones, and subsequently to develop anti-obesity drugs that are based on endogenous hormone agonists or antagonists. The project will include the following aspects and competences: Production of endogenous hormones by synthetic approaches according to the guidelines of GMP and investigation in human volunteers by fMRT. Most promising candidates will be studied in more detail. This will include ghrelin, orexin, GLP, PP and PYY. Experiments will occur on the molecular, cellular and animal level. Original and optimised hormones will be modified with DOTA and used for labelling, and subsequent analysis in PET studies to allow the follow up of distribution and stability. In a medicinal chemistry concept, non peptidic drugs and peptide mimetics will be further explored for PYY and PP first as well as for ghrelin, orexin and GLP.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine medicinal chemistry
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences health sciences infectious diseases
- natural sciences chemical sciences organic chemistry alcohols
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2007-B
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
CP-TP - Collaborative Project targeted to a special group (such as SMEs)
Coordinator
04109 Leipzig
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.