Cel Photoactive mono- and oligonuclear transition metal complexes containing DNA intercalative ligands will be synthesized. In the latter case, both homo- and heterometallic complexes will be synthesized. The photophysical properties of the complexes will be exploited to produce a number of outcomes: prototypical sensors for DNA sequences and/or structures that will produce a luminescent output on DNA binding, tools for investigating DNA/substrate binding events and the photophysical/electronic properties of DNA. The synthesis of multi-functional probes will also be investigated; e.g. DNA light-switches that also cleave DNA (directly OR through singlet oxygen sensitizing) and/or display cytotoxicity. To fully understand the properties of the new systems and their interaction with DNA studies will encompass a wide spectrum of techniques from time resolved optical spectroscopy, to calorimetry and in cellulo studies. Dziedzina nauki natural sciencesbiological sciencesgeneticsDNAnatural scienceschemical sciencesanalytical chemistrycalorimetryengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsnatural sciencesphysical sciencesopticsspectroscopy Słowa kluczowe Chemistry Molecular chemistry Molecular markers and recognition Nanodevices Physical sciences Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) PEOPLE-2007-4-2.IIF - Marie Curie Action: "International Incoming Fellowships" Zaproszenie do składania wniosków FP7-PEOPLE-2007-4-2-IIF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IIF - International Incoming Fellowships (IIF) Koordynator THE UNIVERSITY OF SHEFFIELD Wkład UE € 169 957,94 Adres FIRTH COURT WESTERN BANK S10 2TN Sheffield Zjednoczone Królestwo Zobacz na mapie Region Yorkshire and the Humber South Yorkshire Sheffield Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Gill Wells (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych