Objective
Calcium ion (Ca2+) is one of the most important divalent ions in the day-to-day life of any cell, as shown by its involvement as second messenger in virtually all cell types, from life onset to cell death through almost every physiological processes (muscle contraction, heart physiology, coagulation, immune system control, neuronal information processing). Ca2+ concentration can vary by up to 6 orders of magnitude with dynamics in the millisecond range; however, the investigation of its variations has been hindered by the lack of precise control over the dynamics, especially in excitable cells such as neuron. In this project, we propose to first build a new tool to control in real time the variations of intracellular Ca2+ via the combination of two-photon microscopy and dynamic current clamp: the dynamic calcium clamp. Then, we propose to use this tool to investigate two neurophysiological mechanisms: one related to a new form of synaptic plasticity dependent on the rates of activity of both the pre and post synaptic neurons and the other to the integration of the eye velocity signal into an eye position signal. The conception of the dynamic calcium clamp and its first applications would be undertaken in Boston University, USA, since in this institution hosts both one of the leading laboratory in microscopy applied to Neurosciences (BioMicroscopy Lab, outgoing host) and a laboratory developing one of the best dynamic clamp software (NDL, partner). The last part of the project will be lead at the return host, located in Paris 5 University, FRANCE (LNRS-UMR7060). There, the dendritic properties of the neurons of the velocity to position integrator would be studied, with a special focus on the Goldman hypothesis about dendritic hysteresis which would modify the local computing properties. Thus, this project will at the same time provide new tools, better understanding of brain mechanisms and foster the development of the career of the fellow in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences computer and information sciences software
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences physical sciences optics microscopy
- natural sciences computer and information sciences data science data processing
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-1-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75270 cedex 06 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.