Objective
Small RNA is a specificity determinant of silencing mechanisms that can target RNA through base pairing to affect RNA stability and translation. This targeting process, directly or indirectly, can also target DNA and chromatin to introduce epigenetic modifications. In plants there are many hundreds of thousands - of different small silencing RNAs (sRNAs) produced from many thousands of loci. These sRNAs have enormous potential to influence genetic and epigenetic regulation because, from analysis of transgenes, it is clear that RNA silencing can have diverse effects. There can be RNA-mediated signalling between cells and complex interaction networks of RNA molecules with positive feedback and amplification loops. In addition there can be epigenetic effects that, once induced, can persist between generations. In REVOLUTION the aim is to find out which of the endogenous sRNAs have the various RNA silencing properties revealed by transgenes. The aim is then to integrate these findings into a systems level understanding of regulation and evolution in Arabidopsis. The role of these sRNA systems will be investigated in plants subjected to hormone and stress treatments. We shall also investigate the role of these sRNAs in natural variation between genotypes of plant and their effect in hybrids between these plants. In the final stages of the work it is intended to explore the various effects of endogenous sRNAs in plants other than Arabidopsis including tomato. This work will provide a new level of understanding of the mechanisms affecting gene expression in plants. This fundamental new understanding will affect crop science through conventional breeding and genetic engineering. In addition because RNA silencing takes place in animals including vertebrates there will be relevance of this work beyond plants.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- medical and health sciences medical biotechnology genetic engineering
- social sciences political sciences political transitions revolutions
- agricultural sciences agriculture, forestry, and fisheries agriculture
- natural sciences biological sciences genetics RNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2008-AdG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
CB2 1TN Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.