Objective
Extensive feedback between gene expression state and the cellular environment yields tangled hierarchies . This lack of strictly hierarchical control mechanisms poses a challenge to developmental biologists: the outcome of interaction networks with extensive feedbacks is not intuitive and must be analyzed with analytical tools. Here, I propose a combination of experimental and theoretical approaches to study control mechanisms of plant architecture and their emergent properties. The plant hormone auxin appears to be a major player in developmental patterning and architecture. We and others have shown previously that auxin distribution patterns can self-organize and elaborate different architectures by principles of self-organization. We have discovered that the PLETHORA transcription factors, which form instructive gradients during root development, are involved in early embryo and shoot development as well, and that they constitute a principal component of plant development. Excitingly, PLETHORA genes are regulated by auxin accumulation but they feed back on the most important actors that determine auxin distribution, the PIN proteins. The dynamics of this PLETHORA-PIN loop can display emergent properties that may explain the majority of principal patterning events that determine root and shoot specification as well as branching. Here, I propose to investigate this feedback system in detail using (1) molecular genetic approaches, (2) computer modelling and (3) functional genomics approaches. The projected outcomes are a deep understanding of major control mechanisms for tissue pattern and organismal architecture and general insights into genetic information encoding using tangled hierarchies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2008-AdG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
6708 PB Wageningen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.