Objective
More than 100 million Europeans are affected by arthritis and other rheumatic diseases that cause stiffness, inflammation and swelling in the joints. Notably, pain is one of the most bothersome symptoms reported by this group of people. Pain not only impairs the ability to function and reduces the quality of life, but also forms the basis for an increasing economical burden. According to the European Pain Network, chronic and recurrent pain accounts for nearly 500 million lost working days and a €34 billion hole in the economy every year across Europe. Acute local inflammation is self-limiting and resolves through an active termination program. Lipoxins and resolvins represent novel classes of lipid mediators that function as “braking signals” in inflammation. My recent work has shown that while systemic injection of lipoxins reduces both pain and edema, spinal delivery reduces inflammatory hyperalgesia without altering the peripheral inflammatory state. The lipoxin receptor, ALXR, was found expressed on spinal astrocytes, indicating that not only neurons, but also spinal non-neuronal cells participate in the regulation of pain signaling. The aim with the proposed studies is to 1) expand this work to examine if lipoxin A4 has anti-hyperalgesic effect in models of chronic inflammatory pain using experimental models of arthritis, 2) to include a second representative of anti-inflammatory lipid mediators, resolvins E1, and 3) to explore the hypothesis that pain may be sustained due to an impaired generation of counter-regulatory mediators. In addition, possible molecular mechanism by which lipoxins control astrocyte activation will be explored in astrocyte cultures. These studies promise to provide insights into novel mechanisms of regulation of spinal sensitization and inflammatory pain, shed light onto the role of non-neuronal cells in spinal nociceptive processing and point to novel drug targets for chronic inflammatory pain.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine rheumatology
- natural sciences biological sciences biochemistry biomolecules lipids
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-3-IRG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.